Table 1.
Characteristics of male Agtfl/fl and AgtaP2 mice at 2 and 12 mo of age
2 mo |
12 mo |
|||
---|---|---|---|---|
Agtfl/fl | AgtaP2 | Agtfl/fl | AgtaP2 | |
Body weight, g | 24.6 ± 2.1 | 24.9 ± 2.1 | 38.1 ± 1.6* | 36.7 ± 1.2* |
Fat mass, % | 9.3 ± 2.6 | 8.1 ± 2.6 | 21.1 ± 2.2* | 19.9 ± 2.1* |
Kidney, g | 0.33 ± 0.03 | 0.31 ± 0.03 | 0.52 ± 0.02* | 0.54 ± 0.02* |
Liver, g | 1.40 ± 0.09 | 1.44 ± 0.09 | 1.63 ± 0.06 | 1.61 ± 0.05 |
FG, mg/100 ml | 201 ± 12 | 206 ± 12 | 175 ± 10* | 167 ± 7* |
Leptin, ng/ml | 1.9 ± 0.6 | 3.0 ± 0.5 | 13.6 ± 2.7* | 8.6 ± 1.7* |
Insulin, ng/ml | 0.37 ± 0.04 | 0.28 ± 0.02 | 0.55 ± 0.11* | 0.52 ± 0.06* |
Data are means ± SE; n = 6 mice/group (2 mo), or n = 11–19 mice/group (12 mo). FG, fasting blood glucose.
P < 0.05 compared to 2 mo within genotype.