Table 2.

Characteristics of female Agt^fl/fl and Agt^aP2 mice at 2 and 12 mo of age

	2 mo		12 mo
	Agtfl/fl	AgtaP2	Agtfl/fl	AgtaP2
Body weight, g	21.5 ± 1.5	21.6 ± 2.1	31.3 ± 1.0*	29.2 ± 1.0*
Fat mass, %	8.0 ± 0.4	7.9 ± 0.10	18.7 ± 3.1*	16.1 ± 1.5*
Kidney, g	0.25 ± 0.02	0.26 ± 0.03	0.34 ± 0.01*	0.32 ± 0.01*
Liver, g	1.23 ± 0.10	1.22 ± 0.14	1.47 ± 0.07	1.25 ± 0.07
FG, mg/100 ml	180 ± 11	175 ± 16	126 ± 7*	150 ± 8*
Leptin, ng/ml	0.7 ± 0.1	1.5 ± 0.6	6.9 ± 2.4*	8.8 ± 0.6*
Insulin, ng/ml	0.29 ± 0.02	0.33 ± 0.10	0.36 ± 0.06	0.45 ± 0.09

Data are means ± SE; n = 3–6 mice/group (2 mo), or n = 13–14 mice/group (12 mo).

^*P < 0.05 compared to 2 mo within genotype.