Figure 2.
Localization of α-Syn and LRRK2 mRNA in the brain of transgenic mice. (A) In situ hybridization with 33P-labeled antisense oligonucleotide probes specific to total (human + mouse) or mouse α-Syn, mouse LRRK2 or mouse TH. Autoradiographs indicate the localization of human and mouse α-Syn, or endogenous LRRK2 and TH mRNAs in tissue sections containing the striatum/cortex, hippocampus/substantia nigra (SN) and brainstem from 7-month-old human A53T-α-Syn transgenic mice and their non-transgenic (Non-Tg) littermate control mice. (B) Localization of human or mouse LRRK2 mRNA in brain sections from 9- or 12-month-old human G2019S-LRRK2 transgenic and their non-transgenic mice.