Figure 6.

Detection of NEDD8-immunopositive Lewy bodies. (A) NEDD8 immunoreactivity was detected in the pigmented dopaminergic neurons in control and PD substantia nigra. The pictures are representative NEDD8 staining images from a control (male, 76years) and a PD patient (male, 78years). In total, four pairs of control and PD cases were examined. (B) Lewy bodies in pigmented dopaminergic neurons were stained with an anti-NEDD8 antibody (top panel) and eosin (bottom panel). Lewy bodies are indicated by arrows. Scale bar, 10 µm.