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. 2012 May 2;95(6):1357–1364. doi: 10.3945/ajcn.111.031070

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© 2012 American Society for Nutrition

This is a free access article, distributed under terms (http://www.nutrition.org/publications/guidelines-and-policies/license/) which permit unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIGURE 2. — Random-effects meta-analysis comparing the effects of daily and bolus supplementation of D3 with that of D2 on net changes in serum 25(OH)D concentrations. The forest plot indicates that the absolute change in 25(OH)D from baseline favored the D3 intervention. In the figure, “Δ25(OH)D” denotes the change in serum 25(OH)D concentrations from baseline (net change), squares denote mean differences [with 95% CIs (lines)], and “Total” denotes the cumulative n from all included studies. With the use of a random-effects model, overall, there was a significantly greater effect in the raising of serum 25(OH)D concentrations over time for D3 supplementation than for D2 supplementation (mean difference: 15.23; 95% CI: 6.12, 24.34; P = 0.001). D2, vitamin D₂; D3, vitamin D₃; IV, inverse variance; 25(OH)D, 25-hydroxyvitamin D.