TABLE 4.
Adjusted for age, sex, study site, and population stratification |
Adjusted for age, sex, study site, population stratification, and total energy intake |
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Gene | Single nucleotide polymorphism | Minor allele | β ± SE | P value | β ± SE | P value |
Eating occasions (no./d) | ||||||
TNNI3K | rs1514176 | G | −0.030 ± 0.037 | 0.414 | −0.041 ± 0.036 | 0.255 |
INSIG2 | rs7566605 | C | −0.042 ± 0.038 | 0.263 | −0.037 ± 0.037 | 0.317 |
PPARG | rs1801282 | G2 | 0.153 ± 0.074 | 0.0383 | 0.128 ± 0.073 | 0.080 |
NISCH-STAB1 | rs4687617 | G | 0.027 ± 0.082 | 0.742 | 0.006 ± 0.081 | 0.945 |
BDNF | rs10767664 | T2 | −0.024 ± 0.056 | 0.661 | 0.003 ± 0.055 | 0.951 |
BDNF | rs6265 | A2 | −0.005 ± 0.058 | 0.927 | 0.023 ± 0.057 | 0.682 |
BDNF | rs1401635 | C | −0.054 ± 0.039 | 0.160 | −0.048 ± 0.038 | 0.205 |
MTIF3 | rs7988412 | A | 0.028 ± 0.054 | 0.601 | 0.026 ± 0.053 | 0.623 |
MAP2K5 | rs2241420 | A | −0.023 ± 0.037 | 0.524 | −0.026 ± 0.036 | 0.470 |
SH2B1 | rs4788099 | G2 | −0.003 ± 0.038 | 0.936 | −0.011 ± 0.037 | 0.758 |
FTO | rs1421085 | C | 0.125 ± 0.039 | 0.0014 | 0.109 ± 0.038 | 0.0044 |
FTO | rs3751812 | A | 0.096 ± 0.039 | 0.0143 | 0.081 ± 0.038 | 0.0343 |
FTO | rs9922708 | A | 0.077 ± 0.037 | 0.0393 | 0.063 ± 0.037 | 0.087 |
FTO | rs9939609 | A | 0.087 ± 0.037 | 0.0183 | 0.075 ± 0.036 | 0.0373 |
MC4R | rs17782313 | C | −0.113 ± 0.041 | 0.0063 | −0.112 ± 0.041 | 0.0063 |
QPCTL/GIPR | rs11672660 | A2 | 0.154 ± 0.054 | 0.0053 | 0.146 ± 0.053 | 0.0063 |
All analyses were conducted with multivariable linear regression with the statistical covariates listed in the table (n = 2075).
Because the marker minor allele frequency fell below 20%, the rare genotype was combined with the intermediate genotype.
P values of nominal significance.
Statistical significance after correction for multiple comparisons, or P ≤ 0.004.