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. 2012 May 2;95(6):1487–1494. doi: 10.3945/ajcn.111.032045

TABLE 4.

Baseline and posttreatment hemodynamic measures of study participants1

Variable and timeline Placebo (n = 12) Soy isoflavone treatment (n = 12) P2 P3
Arterial compliance
 SBP (mm Hg)
  Baseline 140.7 ± 7.44 140.1 ± 8.3 0.86
  6 wk 135.9 ± 9.8 137.3 ± 9.7 0.15
 DBP (mm Hg)
  Baseline 82.2 ± 8.7 82.8 ± 6.2 0.85
  6 wk 79.5 ± 7.1 79.9 ± 6.0 0.57
 Large-artery elasticity index (mL/mm Hg · 100)
  Baseline 15.2 ± 8.3 12.3 ± 4.2 0.28
  6 wk 13.8 ± 3.7 13.8 ± 3.8 0.34
 Small-artery elasticity index (mL/mm Hg · 100)
  Baseline 3.1 ± 1.6 3.0 ± 1.5 0.90
  6 wk 3.5 ± 2.2 4.0 ± 2.5 0.61
FBF and vascular resistance
 Baseline FBF (mL · min−1 · 100 g−1 tissue)
  Baseline 2.06 ± 0.62 1.78 ± 0.46 0.22
  6 wk 1.92 ± 0.55 1.55 ± 0.70 0.35
 PRH (mL · min−1 · 100 g−1 tissue)5
  Baseline 23.1 ± 7.4 17.7 ± 3.8 0.03
  6 wk 22.3 ± 8.0 17.0 ± 8.1 0.08
 Vascular resistance (pressure/flow)6
  Baseline 71.1 ± 36.3 77.7 ± 26.8 0.62
  6 wk 74.7 ± 37.5 86.3 ± 30.2 0.52
24-h Ambulatory blood pressure monitoring
 24-h Mean SBP (mm Hg)
  Baseline 132.0 ± 7.0 132.0 ± 6.5 0.99
  6 wk 130.9 ± 8.2 129.7 ± 8.4 0.61
 24-h Mean DBP (mm Hg)
  Baseline 78.5 ± 7.9 78.7 ± 7.6 0.96
  6 wk 77.8 ± 6.3 77.4 ± 6.3 0.62
 24-h Mean HR (beats/min)
  Baseline 78.2 ± 5.3 75.3 ± 5.1 0.19
  6 wk 81.1 ± 9.8 76.2 ± 5.5 0.43
 Daytime mean SBP (mm Hg)
  Baseline 135.6 ± 5.7 137.5 ± 7.9 0.52
  6 wk 134.6 ± 9.9 134.2 ± 6.8 0.59
 Daytime mean DBP (mm Hg)
  Baseline 81.0 ± 8.2 82.6 ± 8.2 0.62
  6 wk 80.2 ± 7.0 81.1 ± 6.7 0.84
 Daytime mean HR (beats/min)
  Baseline 81.6 ± 6.6 77.9 ± 5.9 0.16
  6 wk 84.7 ± 9.2 77.7 ± 5.8 0.12
 Nighttime mean SBP (mm Hg)
  Baseline 124.4 ± 10.4 121.0 ± 11.0 0.45
  6 wk 121.8 ± 7.6 118.9 ± 11.2 0.74
 Nighttime mean DBP (mm Hg)
  Baseline 72.9 ± 7.9 70.0 ± 9.14 0.41
  6 wk 70.6 ± 5.4 68.4 ± 7.0 0.68
 Nighttime mean HR (beats/min)
  Baseline 70.5 ± 8.1 69.9 ± 6.1 0.83
  6 wk 71.7 ± 10.6 71.5 ± 7.4 0.94
 Dipper SBP (fraction)7
  Baseline 0.25 ± 0.45 0.58 ± 0.52 0.11
  6 wk 0.36 ± 0.51 0.67 ± 0.49 0.21
1

DBP, diastolic blood pressure; FBF, forearm blood flow; HR, heart rate; PRH, peak reactive hyperemia; SBP, systolic blood pressure.

2

Derived by using an independent-samples t test for the comparison between the placebo and treatment groups.

3

Derived by using a generalized linear model for the comparison between the placebo and treatment groups with adjustment for baseline measures.

4

Mean ± SD (all such values).

5

Represents the highest FBF after release of the brachial artery occlusion.

6

Change in forearm vascular resistance before ischemia to the maximum reduction in forearm vascular resistance during PRH (flow-mediated vasodilation).

7

Proportion of subjects whose average nighttime SBP dropped >10% compared with their average daytime SBP.