Table 5.

Transition probabilities for accumulated mutations C1-C4

	G+	G-	P+T+	P-T-	P+T-	P-T+
C1
G+	0.212	0	0.082	0.071	0	0
G-	0	0.235	0	0	0.010	0
P+T+	0.035	0	0.113	0.052	0	0
P-T-	0.030	0	0.052	0.082	0	0
P+T-	0	0.020	0	0	0.007	0
P-T+	0	0	0	0	0	0
C2
G+	0.005	0	0.008	0.006	0	0
G-	0	0.822	0	0	0.018	0
P+T+	0.006	0	0.013	0.011	0	0
P-T-	0.008	0	0.014	0.018	0	0
P+T-	0	0.056	0	0	0.016	0
P-T+	0	0	0	0	0	0
C3
G+	0.247	0	0.026	0	0	0
G-	0	0.222	0	0	0.050	0.043
P+T+	0.016	0	0.008	0	0	0
P-T-	0	0	0	0	0	0
P+T-	0	0.100	0	0	0.118	0
P-T+	0	0.086	0	0	0	0.086
C4
G+	0.825	0	0.069	0	0	0
G-	0	0	0	0	0.005	0.005
P+T+	0.042	0	0.011	0	0	0
P-T-	0	0	0	0	0	0
P+T-	0	0.011	0	0	0.011	0
P-T+	0	0.011	0	0	0	0.011