Table 2.
Univariate analysis of the association between prognosis and various clinicopathologic parameters in patients with PGC
| Features | Overall survival | Disease-free survival | ||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P | |
| Gender (Male vs. Female) | 0.672 | 0.328-1.296 | NS | 1.007 | 0.426-2.335 | NS |
| Age (≤ 66 years vs.≥ 66 years) | 0.766 | 0.357-1.402 | NS | 0.890 | 0.368-1.563 | NS |
| Tumor size (≤ 2.5 cm vs.≥ 2.5 cm) | 0.819 | 0.334-1.628 | NS | 1.023 | 0.269-2.682 | NS |
| Histological grade (G1-G2 vs. G3± G4) | 0.981 | 0.365-2.879 | NS | 1.107 | 0.319-2.989 | NS |
| Pathologic T stage (T1± T2 vs. T3 ± T4) | 3.387 | 1.528-8.336 | 0.008 | 3.072 | 1.269-8.668 | 0.02 |
| Clinical stage (I± II vs. III ± IV) | 5.620 | 1.591-11.072 | < 0.001 | 4.863 | 1.893-10.651 | 0.001 |
| Nodal metastasis (Negative vs. Positive) | 4.701 | 1.310-8.543 | 0.001 | 4.663 | 1.700-10.253 | 0.001 |
| Distant metastasis (Negative vs. Positive) | 4.509 | 1.271-9.775 | 0.001 | 2.181 | 1.037-4.357 | NS |
| Venous/lymphatic invasion (Negative vs. Positive) | 2.687 | 1.190-5.053 | NS | 2.508 | 1.431-4.383 | NS |
| Perineural invasion (Negative vs. Positive) | 1.216 | 1.087-3.126 | NS | 1.246 | 1.507-3.608 | NS |
| SOX4 expression (Negative vs. Positive) | 3.237 | 1.221-7.952 | 0.01 | 3.782 | 1.339-8.862 | 0.02 |
Note: 'NS' refers to 'No statistic significance'