Figure 4.

TRPM2 deficiency has no effect on the tobacco smoke-induced BAL inflammation and lung cytokine production. TRPM2-deficient mice (gray bars) or their wild type counterpart (white bars) were exposed to tobacco smoke (hatched bars) or air (plain bars) as described in methods. Animals were killed for bronchoalveolar lavage differential cell counts and bronchoalveolar lavage and lung soluble mediator measurement 18 hours after the end of last exposure. Data are shown as mean ± SEM of 10-11 animals per group. Significance (P < 0.05), indicated by *, is against the air-exposed mice for each strain. No statistical significance was observed between deficient and wild type animals on all the parameters measured.