Figure 6.

TRPM2 deficiency has no effect on the tobacco smoke/LPS-induced BAL inflammation. TRPM2-deficient mice (gray bars) or their wild type counterpart (white bars) were sham-exposed (plain bars) or exposed to LPS (horizontal hatched bars), tobacco smoke (left hatched bars, TS) or their combination (right hatched bars, TS/LPS) as described in methods. Animals were killed for bronchoalveolar lavage differential cell counts and soluble mediator measurement 18 hours after the end of last exposure. Data are shown as mean ± SEM of 9-11 animals per group. Significance (P < 0.05), indicated by *, is against the air-exposed mice for each strain. No statistical significance was observed between deficient and wild type animals on all the parameters measured.