Fig. 3.
A: typical traces recorded in gap-free mode at +10 mV membrane Vhold in standard ACSF for MSNs with low-frequency (LF) and high-frequency (HF) inhibitory postsynaptic currents (IPSCs) from CAG160 R6/2s at 80 days and an age-matched WT. B: bar graphs show mean (±SE) spontaneous IPSC frequency for LF and HF cells for each CAG repeat line at the ages indicated. At 21 days, data were obtained only from the CAG160 line and their WTs. ***P < 0.001 with respect to WT. C: proportion of HF cells in each CAG repeat line.