Table 1.

Summary of measures displaying inverted U-shaped function

	Age (Days)
	20/30	40	60	80
Capacitance		N		√
Input resistance		√		√
EPSC frequency		√		√
EPSC-BIC frequency		√		√
IPSC frequency		N		N
Proportion of cells with high frequency IPSCs		√		√
NMDA peak current (Mg2+-free)	N	N		N
NMDA current density (Mg2+-free)	N	√		N
NMDA peak current (50 μM Mg2+)	√	√		N
NMDA current density (50 μM Mg2+)	√	√		N
NMDA 50 μM Mg2+ % baseline	√	√		√
Body weight	N	N	N	√
Hind-limb clasping	N	N	N	N
rotarod	N	√	√	√
Pole test	N	N	N	N
Seizure susceptibility	√
Diffuse nuclear staining	N	N		√
Nuclear microaggregates	N	N		√
Neuronal intranuclear inclusions	N	√		√
Neuropil aggregates	N	N		N

√ indicates that an inverted U-shaped function was displayed. N indicates that an inverted U-shaped function was not displayed. Blank indicates the measure was not, or could not be, assessed. EPSC, excitatory postsynaptic current; BIC, bicuculline methobromide; IPSC, inhibitory postsynaptic current; NMDA, N-methyl-d-aspartate.