Table 2. Separation of clusters of the NCI cell line panel obtained by the hierarchical cluster analysis shown in Figure 3 in comparison to drug sensitivity.
Partitiona | Cluster 1 | Cluster 2 | Cluster 3 | Chi2 Test | ||
formulated arsenic trioxide | sensitive | ≤−5.346 | 2 | 22 | 6 | |
resistant | >−5.346 | 20 | 10 | 0 | 3.32635×10−6 | |
free arsenic trioxide | sensitive | ≤−5.467 | 2 | 21 | 6 | |
resistant | >−5.467 | 20 | 10 | 0 | 4.50505×10−6 |
The median log10IC50 value (M) for each drug was used as a cut-off to separate tumor cell lines as being "sensitive" or "resistant".