Figure 2. Silencing of FOXA1 in RT4 cells results in increased expression of UPK family members.

A: Stable knockdown of FOXA1 in human RT4 bladder cancer cells (See Figure 6 for FOXA1 protein levels following knockdown in RT4). B: No significant changes in UPK1A were detected following FOXA1 KD. (C-F): mRNA levels of UPK1B, UPK2, UPK3A, and UPK3B were significantly increased following FOXA1 knockdown.