Table 1.

Passive and firing properties

Measure	Significance	Direction	wt 0 μΜ	SOD1 0 μΜ	wt 2 μΜ	SOD1 2 μΜ
Cell size			N = 57	N = 32	N = 59	N = 40
Diameter, μm	ns		25.7 ± 4.9	25.2 ± 3.5	26.0 ± 4.3	26.6 ± 4.4
Passive properties			N = 57	N = 32	N = 59	N = 40
RMP, mV	Drug*	0 > 2	−50.5 ± 6.4	−49.2 ± 5.5	−52.7 ± 7.0	−52.0 ± 7.4
Capacitance, pF	Ns		30.4 ± 17.5	34.0 ± 16.6	33.5 ± 14.3	31.2 ± 10.6
			N = 47	N = 25	N = 52	N = 30
Leak conductance, nS	Genotype*	WT > SOD1	2.8 ± 1.3	2.6 ± 1.3	2.9 ± 1.6	2.1 ± 1.0
AP and FI data			N = 57	N = 31	N = 59	N = 38
Height (>0 mV)	Ns		32.4 ± 6.8	32.8 ± 6.7	32.9 ± 8.0	32.2 ± 7.0
Voltage threshold, mV	Ns		−31.7 ± 3.8	−32.7 ± 5.1	−33.4 ± 4.5	−32.1 ± 3.6
			N = 56	N = 25	N = 56	N = 37
Current threshold, pA	Genotype*	WT > SOD1	26.8 ± 41.6	5.4 ± 32.0	28.2 ± 54.5	19.3 ± 34.9
			N = 56	N = 30	N = 54	N = 35
ΔI, pA	Ns		−29.7 ± 18.3	−24.3 ± 13.7	−31.4 ± 21.9	−27.7 ± 13.9
Ascending gain, Hz/pA	Ns		0.240 ± 0.09	0.251 ± 0.09	0.233 ± 0.12	0.227 ± 0.08
			N = 50	N = 28	N = 51	N = 31
Descending gain, Hz/pA	Ns		0.382 ± 0.15	0.366 ± 0.15	0.346 ± 0.15	0.370 ± 0.13
			N = 19	N = 20	N = 8	N = 7
Spont. activity, AP/min			71.5 ± 152	176.6 ± 197	139.5 ± 193	71.2 ± 152

Means ± SD for each of the 4 individual groups are presented separately (genotype:drug): wild type (wt) control (0 μM), superoxide dismutase 1 mutant (SOD1) control (0 μM), wt riluzole (2 μM), and SOD1 riluzole (2 μM). The number of cells per group (N) is above each series of measurements. RMP, resting membrane potential; AP, action potential; FI, frequency-current; ΔI, difference between current at AP recruitment and derecruitment; Spont., spontaneous. Significant differences for drug, genotype, and interactions are listed in a separate column. Significance: not significant (ns),

^*0.05 ≥ P > 0.01. The direction of each significant difference is listed in a separate column. The direction is based on actual, not absolute, values.