Table 2.

PIC, NaPIC, and TTX-ins measures

Measure	Significance	Direction	wt 0 μΜ	SOD1 0 μΜ	wt 2 μΜ	SOD1 2 μΜ
PIC			N = 46	N = 25	N = 51	N = 30
Onset, mV	Drug**	0 > 2	−42.5 ± 5.0	−45.5 ± 3.0	−46.1 ± 5.1	−46.2 ± 3.9
	Genotype*	wt > SOD1
Max voltage, mV	Drug****	0 > 2	−28.5 ± 4.7	−29.0 ± 2.6	−32.0 ± 4.1	−32.1 ± 3.1
Amplitude, pA	Drug**	0 < 2	−36.8 ± 28.6	−57.9 ± 58.7	−33.8 ± 25.3	−25.8 ± 18.9
	Interaction**	SOD1: 0 < 2
		SOD1 0 < wt 2
NaPIC			N = 35	N = 20	N = 39	N = 22
Onset, mV	Drug*	0 > 2	−48.6 ± 6.6	−49.2 ± 3.9	−51.5 ± 3.5	−50.4 ± 4.4
Max voltage, mV	Drug*	0 > 2	−24.5 ± 4.8	−26.0 ± 3.8	−26.7 ± 4.4	−28.0 ± 5.4
Amplitude, pA	Ns		−74.7 ± 45.3	−73.9 ± 41.8	−68.3 ± 25.4	−56.6 ± 27.7
TTX-ins			N = 30	N = 20	N = 38	N = 21
Onset, mV	Genotype**	wt < SOD1	−53.4 ± 12.9	−45.7 ± 8.8	−54.0 ± 11.0	−48.1 ± 13.4
Amp, PIC max	Genotype*	wt > SOD1	43.9 ± 30.3	28.7 ± 14.5	45.1 ± 49.2	32.1 ± 23.0

Means ± SD for each of the 4 individual groups are presented separately (genotype:drug): wt control (0 μM), SOD1 control (0 μN), wt riluzole (2 μM), and SOD1 riluzole (2 μM). The number of cells per group (N) is above each series of measurements. PIC, persistent inward current; NaPIC, sodium PIC; TTX-ins, TTX-insensitive current; Amp, amplitude. Significant differences for drug, genotype and interactions are listed in a separate column. Significance: not significant (ns),

^*0.05 ≥ P > 0.01,

^**0.01 ≥ P > 0.001,

^****P ≤ 0.0001. The direction of each significant difference is listed in a separate column. The direction is based on actual, not absolute, values.