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. 2001 May 8;98(11):6500–6505. doi: 10.1073/pnas.101545198

Figure 3.

Figure 3

Biochemical changes in mice transplanted with CHO cells producing FGF23. Time course of changes of serum phosphate level (A), renal phosphate excretion index (B), and serum alkaline phosphatase activity (C) in nude mice bearing CHO-FGF23 cells (n = 6; ▴) were compared with those in mice with wild-type CHO cells (n = 6; ■) and control nude mice without CHO cells (n = 6; ○). Blood and 24-h urine samples were collected on days 1, 6, 20, and 45 after the implantation. Renal phosphate excretion index was urinary phosphate divided by serum phosphate and urinary creatinine. Data are means ± SEM at each time point. Significant difference from control group by one-way ANOVA followed by Dunnett's multiple comparison test; *, P < 0.05; **, P < 0.01; ***, P < 0.001.