Figure 5.
(A) Typical appearance of a mouse bearing CHO-FGF23 cell tumors. (B) Whole skeletal soft roentgenogram of a mouse bearing wild-type CHO cell tumors (Left) and a mouse bearing CHO-FGF23 cell tumors (Right) on day 45 after implantation. (C) Soft roentgenogram of femurs isolated from control mice (Left) and mice bearing CHO-FGF23 cell tumors (Right). (D) Histological appearance of proximal metaphysis of tibia from a control mouse (Upper) and a mouse bearing CHO-FGF23 (Lower) on day 45. The undecalcified tissue sections were subjected to the Villanueva bone stain and the Villanueva-Goldner stain to discriminate mineralized bone tissues (green) from osteoid tissues (pink).