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. 2012 May 10;7(5):e36501. doi: 10.1371/journal.pone.0036501

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Savic et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The association interval within the TCF7L2 gene locus is highlighted in red above. A red asterisk marks SNP rs7903146. Sequence conservation between human-opossum (ECR genome browser, [43]) is given for the entire association interval while the sequence tested is highlighted in green. Within the tested region, sequence conservation between human-opossum is given below (ECR genome browser). Positions of regions spanning SNP rs7903146 (5-C and 5-T) as well as a shorter sequence limited to the downstream ECR (5B) are shown below. (B)-(D) Images of pancreas (attached to the stomach) (left) and brain (right, dorsal view) obtained from independent transgenic lines (rows) are shown at E15.5 or E16.5 (ECR 5-C row 3 only). (B) and (C) Regions 5-C and 5-T exhibits inconsistent pancreatic staining while maintaining reproducible forebrain expression. (B) Construct 5B harbors forebrain expression but no pancreatic staining.