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. 2012 May 10;8(5):e1002690. doi: 10.1371/journal.pgen.1002690

Figure 3. Gata4 G295Ski/ki mice display growth retardation and a thin myocardium.

Figure 3

Right (A,D,G), left (B,E,H) and frontal (C,F,I) views of embryos are shown. Growth retardation of Gata4 G295Ski/ki E9.5 embryos (G,H) when compared to wildtype (A,B) and heterozygote littermates (D,E). A fused heart tube with proper looping is found in Gata4 G295Ski/ki embryos (I) simlar to wildtype (C) and Gata4 G295Ski/wt (F) littermates. Coronal sections through Gata4 G295Ski/wt (J,K) and Gata4 G295Ski/ki (L,M) embryos at E9.5 (J,L) and E10.5 (K,M). Normal myocardial thickness is found at E9.5 in homozygous mutant embryos (L) while thin myocardium is seen at E10.5 (M) when compared to heterozygote littermate (K). Quantification of ventricular wall thickness in Gata4 G295Ski/wt and Gata4 G295Ski/ki embryos at E9.5 (N) and 10.5 (O). RV, right ventricle; LV, left ventricle; red arrow, heart; A, atria; V, ventricle; OFT, outflow tract. Scale bars indicate 200 µm.