Figure 5. Cognitive performance in Exon 1A mice and littermate controls.

(a) A schematic representation of the “switch task” in which a mouse self-initiates the trial (“START”) and receives a reward according to the duration of the signal (“short-latency” versus “long-latency”) and the location (“A” or “B”). (b) The cumulative distribution of all switch latencies (the time at which the mouse stops nose poking in the short-location and moves to the long location) for all long-signal trials are reported for the +/Ex1a mice and their littermate controls. (c) From the above cumulative distribution of the switch latencies we have derived the Time Accuracy (TA), as the median (Q_0.5), and the Time Precision (TP), as the difference of the third and first inter-quartiles (Q_0.75−Q_0.25), similar to what is described in [22]. Box-plots of TAs (the median values for each subject) and TPs (the inter-quartiles) are shown as well as (d) the percentage of correct versus error trials for the whole experiment. The correct/error trials graph refers only to the “Switch” condition, however, the same trend was observed in the “Probes” condition.