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. 2012 May 10;8(5):e1002689. doi: 10.1371/journal.ppat.1002689

Figure 3. 1,25D3 induces autophagy in human macrophages co-infected with HIV and M. tuberculosis.

Figure 3

HIV (A), M. tuberculosis (TB) (B), and HIV/TB dual infected MDM (C) were treated for 7 days with 100 pmol/L 1,25D3, harvested and stained for HIV p17, mycobacteria, and saponin-resistant LC3B-II. Representative density plots from three donors are shown. (D) HIV/M. tuberculosis infected MDM (C) were treated for 7 days with 100 pmol/L 1,25D3, harvested and stained for HIV p17, mycobacteria, and saponin-resistant LC3B-II. Left, representative density plots from three donors from HIV/M. tuberculosis infected MDM are shown for HIV/M. tuberculosis co-infection. Right, histograms of saponin-resistant LC3B-II in macrophages that were HIV+ M. tuberculosis − or HIV+ M. tuberculosis + at day 7 post-infection.