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. 2012 May 10;8(5):e1002709. doi: 10.1371/journal.ppat.1002709

Figure 6. Cross-reactivity of individual Vα2 or non-Vα2 CD4+ T cells.

Figure 6

(A) Frequency of env124-138YS-reactive cells in Vα2 or non-Vα2 CD4+ T cells isolated from either B6 (B6-EF4.1) or Emv2-deficient B6 (B6-EF4.1 Emv2 −/−) EF4.1 mice. Data are the means ± SEM (n = 9) of 18-hr stimulations from 3 experiments. (B–C) IL-2 production in response to stimulation with 5×10−6 M env124-138L (L), env124-138Y (Y) or env124-138YS (YS) in comparison with the absence of peptide stimulation (-) of Vα2 or non-Vα2 env124-138L-reactive hybridoma T cell lines derived from Emv2 +/+ (B) or Emv2 −/− (C) EF4.1 mice.