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. Author manuscript; available in PMC: 2013 May 10.
Published in final edited form as: J Med Chem. 2012 Apr 20;55(9):4159–4168. doi: 10.1021/jm201609k

Table 3.

Agonist and antagonist activities of peptide sequences of interest. Upper panel: Agonist activity of peptides in U937 cells is displayed as Log EC50 (± SEM), EC50 in nM and as a calculated maximum (M) relative to the response of the cells to 10 μM of the C3aR agonist, FLPLAR. Lower panel: Antagonists activity of peptides in U937 cells is displayed as Log IC50 (± SEM), IC50 in nM and as a calculated minimum (M) relative to the response of the cells to 10 μM of the C3aR agonist, FLPLAR, following treatment with the peptides of interest. n = 3–6

# Name Log EC50 EC50 (nM) M (%)
7 SQ110-4 −6.10 (0.18) 797 81
8 SQ060-4 −6.31 (0.22) 487.4 74
9 SQ007-5 −4.58 (0.39) 2002 62
10 SQ002-5 −6.18 (0.31) 654.9 59
# Name Log IC50 IC50 (nM) M (%)
9 SQ007-5 −5.05 (0.21) 8946 0
10 SQ002-5 −5.95 (0.34) 1121 6