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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Nutr Cancer. 2012 Apr 6;64(4):493–502. doi: 10.1080/01635581.2012.667862

Fig. 1. Effects of resveratrol on AhR/Nrf2 signaling pathways.

Fig. 1

For a detailed description of AhR and Nrf2 signaling, refer to the text. Briefly, (A) PAH binds AhR (bound by the complex) and facilitates AhR translocation to the nucleus, where it forms a heterodimer with ARNT. The AhR/ARNT heterodimer then binds and trans-activates XRE-driven phase I/II enzyme promoters and initiates carcinogenesis (12). Resveratrol is demonstrated to inhibit AhR/ARNT recruitment to the promoter (red line; see text for references) and is speculated to displace PAH ligand binding and stabilize the cytosolic AhR complex (dotted green arrow; see text for reference). (B) Resveratrol-induced Nrf2 signaling confers protection against activated phase I enzymes (see text for references). Resveratrol promotes Nrf2 dissociation from Keap1 and nuclear translocation. In the nucleus, Nrf2 forms a heterodimer with small Maf proteins and trans-activates ARE-driven gene promoters (17).