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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Adv Drug Deliv Rev. 2012 Jan 28;64(12):1189–1204. doi: 10.1016/j.addr.2012.01.012

Figure 10.

Figure 10

Treatment of mCherry-labeled MG-63-Ras osteosarcoma tumor-bearing mice with free ALN and TNP-470, HPMA copolymer-ALN-TNP-470 conjugate, or vehicle alone. (A) Structure of the HPMA copolymer-ALN-TNP-470 conjugate. (B) Intravital non-invasive fluorescence imaging of the tumor. (C) Tumor volume of mCherry-labeled MG-63-Ras tumor-bearing mice treated with free ALN and TNP-470 (open triangles), HPMA copolymer-ALN-TNP-470 conjugate (closed triangles), or vehicle alone (closed squares) [80].