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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Adv Drug Deliv Rev. 2012 Jan 28;64(12):1189–1204. doi: 10.1016/j.addr.2012.01.012

Figure 3.

Figure 3

Structures of several bone-targeting molecules including tetracycline as well as minimalized tetracycline (3-amino-2,6-dihydroxybenzamide) and its conjugate with estradiol [29]. Also shown, are the structures of several bisphosphonates in comparison with pyrophosphate. Acidic oligopeptides such as aspartic acid (shown) or glutamic acid 4-10 amino acids long are also excellent bone-targeting molecules.