Table II.

Activity for SCH 727965 against the PPTP in vivo xenograft panel

Xenograft Line	Histology	KM Estimate of Median Time to Event	P-value1	EFS T/C	Median Final RTV	T/C	P-value2	T/C Activity	EFS Activity	Response Activity
KT-14	Rhabdoid	32.6	<0.001	1.7	>4	0.47	<0.001	Low	Low	Int
KT-12	Rhabdoid	34.2	<0.001	3.7	>4	0.34	<0.001	Int	Int	Int
KT-10	Wilms	13	0.074	1.1	>4	0.8	0.633	Low	Low	Low
KT-11	Wilms	16	0.006	1.4	>4	0.43	0.007	Int	Low	Low
KT-13	Wilms	25.2	0.079	1.3	>4	0.58	0.075	Low	Low	Low
SK-NEP-1	Ewing	14.2	<0.001	1.6	>4	0.36	<0.001	Int	Low	Int
EW5	Ewing	10.2	0.002	1.6	>4	0.71	0.005	Low	Low	Int
EW8	Ewing	17.6	<0.001	2.7	>4	0.47	<0.001	Low	Int	Int
TC-71	Ewing	11.9	0.66	1.2	>4	0.95	1	Low	Low	Low
CHLA258	Ewing	25.1	0.442	1.2	>4	0.76	0.37	Low	Low	Low
Rh10	ALV RMS	> EP	<0.001	> 3.0	>4	0.48	<0.001	Low	Int	Int
Rh28	ALV RMS	25	0.629	1.3	>4	0.7	0.436	Low	Low	Low
Rh30	ALV RMS	16.6	0.011	2.4	>4	0.65	0.002	Low	Int	Int
Rh30R	ALV RMS	13.9	0.004	1.3	>4	0.82	0.105	Low	Low	Low
Rh41	ALV RMS	19.8	<0.001	2.1	>4	0.74	0.015	Low	Int	Int
Rh18	EMB RMS	17.8	<0.001	2.6	>4	0.49	<0.001	Low	Int	Int
BT-28	Medulloblastoma	12.3	0.021	1.4	>4	0.67	0.043	Low	Low	Low
BT-45	Medulloblastoma	6	0.842	1.1	>4	0.91	0.368	Low	Low	Low
BT-50	Medulloblastoma	> EP	0.029	> 1.7	3.4	0.75	0.105	Low	NE	Int
BT-41	Ependymoma	> EP	0.146	.	1.3	0.56	0.01	Low	NE	Int
BT-44	Ependymoma	11.9	0.661	1	>4	1.01	0.393	Low	Low	Low
GBM2	Glioblastoma	11.2	0.038	1.2	>4	0.74	0.011	Low	Low	Low
BT-39	Glioblastoma	14.9	0.577	1.1	>4	0.83	0.481	Low	Low	Low
D645	Glioblastoma	13	0.039	2	>4	0.66	0.035	Low	Low	Int
NB-SD	Neuroblastoma	10.1	<0.001	1.5	>4	0.61	0.001	Low	Low	Low
NB-1771	Neuroblastoma	16	0.815	1	>4	1.05	0.798	Low	Low	Low
NB-1691	Neuroblastoma	8.6	0.446	1.4	>4	0.8	0.36	Low	Low	Low
NB-EBc1	Neuroblastoma	12.7	<0.001	2.4	>4	0.49	<0.001	Low	Int	Int
CHLA-79	Neuroblastoma	13.1	0.003	1.5	>4	0.76	0.015	High	Low	Low
NB-1643	Neuroblastoma	7.9	0.203	1.2	>4	0.87	0.356	Low	Low	Low
OS-1	Osteosarcoma	> EP	0.477	.	0.9	0.54	<0.001	Low	NE	Int
OS-2	Osteosarcoma	27.5	<0.001	1.5	>4	0.67	0.006	Low	Low	Low
OS-17	Osteosarcoma	27.5	<0.001	1.7	>4	0.63	<0.001	Low	Low	Int
OS-9	Osteosarcoma	28.2	0.02	1.3	>4	0.84	0.19	Low	Low	Low
OS-33	Osteosarcoma	24.4	<0.001	1.2	>4	0.73	0.011	Low	Low	Low
OS-31	Osteosarcoma	25.9	<0.001	1.8	>4	0.46	<0.001	Low	Low	Int
ALL-2	ALL B-precursor	26.4	<0.001	1.7	>25	.			Low	Int
ALL-4	ALL B-precursor	5	0.029	0.8*	>25	.			Low	Low
ALL-7	ALL B-precursor	6.7	0.561	1.2	>25	.			Low	Low
ALL-8	ALL T-cell	5	0.023	0.9*	>25	.			Low	Low
ALL-16	ALL T-cell	> EP	0.025	> 1.5	1.1	.			NE	High
ALL-17	ALL B-precursor	> EP	<0.001	> 4.6	0.9	.			High	High
ALL-19	ALL B-precursor	4.3	0.189	0.7*	>25	.			Low	Low

¹P-value for EFS distribution for treated versus control. In bold are values that demonstrate significant growth delay.

²P-value for tumor volume Tumor Volume T/C for treated versus control.

^*xenografts that showed <1 T/C ratios.