Figure 2.

RvD1, AT-RvD1, and their stable analogs directly act on hGPR32. Ligand-receptor interactions were determined using the GPR32 β-arrestin system as in Figure 1. Dose-response activation curves are shown for RvD1 and DHA (A), RvD1-ME (B), 17(R/S)-methyl RvD1-ME (C), and AT-RvD1 (D). Results are expressed as mean ± SEM (n = 4 to 6). RLU, relative luminescence units.