Figure 4.

Cytokine and chemokine gene profiling in carotids from Axl chimeras. A–C: Effects of Axl deletion in both BM and non-BM lineages (A), in BM cells (B), and in non-BM cells (C). Individual genes are represented as dots on the volcano plots, in which log₂-transformed fold changes in gene expression are plotted against P values. Vertical lines indicate zero and both positive and negative cutoffs; the horizontal line indicates the significance level (P = 0.05). Genes listed to the left of the zero line (negative values) are down-regulated; those to the right (positive values) are up-regulated. Groups of genes indicated by type style (black, gray, or italic) are as discussed in the text. Expression data were obtained from three carotids per group.