Table 1.
Molecular and biochemical characteristics of the presently characterized five prominent human plakophilin splice variant forms and the chromosomal position of the three genes
| Splice VarianTs | Accession number | Chromosome localization | Size of mRNA (bp) | No. of amino acids | Mol. wt (calc.) | Isoelectric point (calc.) | No. of arm-repeat units | |
|---|---|---|---|---|---|---|---|---|
| Plakophilin-1 | Pkp1a | NM_000299.3 | 1q32 | 5,384 | 726 | 80,496 | 9.18 | 9 |
| Pkp1b | NM_001005337.2 | 5,447 | 747 | 82,860 | 9.29 | 9 | ||
| Plakophilin-2 | Pkp2a | NM_001005242 | 12p11a | 4,307 | 837 | 92,756 | 9.35 | 9 |
| Pkp2b | NM_004572 | 4,439 | 881 | 97,415 | 9.39 | 9 | ||
| Plakophilin-3 | Pkp3 | NM_007183 | 11p15 | 2,845 | 797 | 87,082 | 9.39 | 9 |
aFor Pkp2, a pseudogen at chromosome 12p13 has also been characterized (Bonné et al. 2000).