Table 1.

Histomorphometric Examination of Long Bones in 4-Month-Old WT and A_2AKO Mice

Variable	WT mice	A2AKO mice
BV/tissue volume ratio	22.61 ± 2.154	17.49 ± 0.98⁎
Trabecular no. (mm−1)	5.8 ± 0.07	4.4 ± 0.15⁎⁎
Trabecular separation (μm)	0.13 ± 0.004	0.19 ± 0.006⁎⁎
Cortical area (mm2)	0.68 ± 0.04	0.6 ± 0.016⁎
Total area (mm2)	1.5 ± 0.03	1.3 ± 0.02⁎
BMD (HA/cm3)	0.053 ± 0.0025	0.049 ± 0.0016⁎⁎⁎
BMC (g)	0.48 ± 0.051	0.43 ± 0.028⁎⁎⁎
Outer perimeter (mm)	4.6 ± 0.04	4.4 ± 0.04⁎⁎⁎
TMC (g)	1.9 ± 0.12	1.7 ± 0.05⁎
TRAP-positive osteoclasts (no./lpf)	35 ± 1	50 ± 13⁎⁎⁎

Data are expressed as the mean ± SEM of three independent animals and related to control.

BMC, bone mineral content; HA, hydroxyapatite; lpf, low-power field; TMC, trabecular mineral content.

^⁎P < 0.5,

^⁎⁎P < 0.005, and

^⁎⁎⁎P < 0.01.