Table 2.

List of celiac disease relevant T-cell epitopes recognized by CD4⁺ T cells

Epitopea	Previous names	Peptide-binding registerb									Reference
		1	2	3	4	5	6	7	8	9
DQ2.5 restricted epitopes
DQ2.5-glia-α1a	DQ2-α-I, α9	P	F	P	Q	P	E	L	P	Y	(Arentz-Hansen et al. 2000)
DQ2.5-glia-α1b	DQ2-α-III	P	Y	P	Q	P	E	L	P	Y	(Arentz-Hansen et al. 2002)
DQ2.5-glia-α2	DQ2-α-II, α2	P	Q	P	E	L	P	Y	P	Q	(Arentz-Hansen et al. 2000)
DQ2.5-glia-α3	glia-α20	F	R	P	E	Q	P	Y	P	Q	(Vader et al. 2002b)
DQ2.5-glia-γ1	DQ2-γ-I	P	Q	Q	S	F	P	E	Q	Q	(Sjöström et al. 1998)
DQ2.5-glia-γ2	DQ2-γ-II, γ30	I	Q	P	E	Q	P	A	Q	L	(Qiao et al. 2005; Vader et al. 2002b)
DQ2.5-glia-γ3	DQ2-γ-III	Q	Q	P	E	Q	P	Y	P	Q	(Arentz-Hansen et al. 2002)
DQ2.5-glia-γ4a	DQ2-γ-IV	S	Q	P	E	Q	E	F	P	Q	(Arentz-Hansen et al. 2002)
DQ2.5-glia-γ4b	DQ2-γ-VIIc	P	Q	P	E	Q	E	F	P	Q	(Qiao et al. 2005)
DQ2.5-glia-γ4c	DQ2-γ-VIIa	Q	Q	P	E	Q	P	F	P	Q	(Arentz-Hansen et al. 2002)
DQ2.5-glia-γ4d	DQ2-γ-VIIb	P	Q	P	E	Q	P	F	C	Q	(Qiao, unpublished)
DQ2.5-glia-γ5	DQ2-γ-VI	Q	Q	P	F	P	E	Q	P	Q	(Arentz-Hansen et al. 2002)
DQ2.5-glia-ω1	DQ2-ω-I	P	F	P	Q	P	E	Q	P	F	(Tye-Din et al. 2010)
DQ2.5-glia-ω2	DQ2-ω-II	P	Q	P	E	Q	P	F	P	W	(Tye-Din et al. 2010)
DQ2.5-glut-L1	glutenin-17	P	F	S	E	Q	E	Q	P	V	(Vader et al. 2002b)
DQ2.5-glut-L2	glutenin-156	F	S	Q	Q	Q	E	S	P	F	(Stepniak et al. 2005; Vader et al. 2002b)
DQ2.5-hor-1	Hor-α9, Hα9	P	F	P	Q	P	E	Q	P	F	(Tye-Din et al. 2010; Vader et al. 2003a)
DQ2.5-hor-2	Hor-α2, Hα2	P	Q	P	E	Q	P	F	P	Q	(Vader et al. 2003a)
DQ2.5-hor-3	hor-I-DQ2	P	I	P	E	Q	P	Q	P	Y	(Tye-Din et al. 2010)
DQ2.5-sec-1	Sec-α9, Sα9	P	F	P	Q	P	E	Q	P	F	(Tye-Din et al. 2010; Vader et al. 2003a)
DQ2.5-sec-2	Sec-α2, Sα2	P	Q	P	E	Q	P	F	P	Q	(Vader et al. 2003a)
DQ2.5-ave-1a	Av-α9A	P	Y	P	E	Q	E	E	P	F	(Arentz-Hansen et al. 2004; Vader et al. 2003a)
DQ2.5-ave-1b	Av-α9B, 1490	P	Y	P	E	Q	E	Q	P	F	(Arentz-Hansen et al. 2004; Vader et al. 2003a)
DQ2.2 restricted epitopes
DQ2.2-glut-L1	glutenin-17	P	F	S	E	Q	E	Q	P	V	(Bodd et al. 2012)
DQ8 restricted epitopes
DQ8-glia-α1	DQ8-α-I	E	G	S	F	Q	P	S	Q	E	(van de Wal et al. 1998b)
DQ8-glia-γ1a	DQ8-γ-Ia	E	Q	P	Q	Q	P	F	P	Q	(Tollefsen et al. 2006)
DQ8-glia-γ1b	DQ8-γ-Ib	E	Q	P	Q	Q	P	Y	P	E	(Tollefsen et al. 2006)
DQ8-glut-H1	HMW-glutenin	Q	G	Y	Y	P	T	S	P	Q	(van de Wal et al. 1999)
DQ8.5 restricted epitopes
DQ8.5-glia-α1	DQ8-α-I	E	G	S	F	Q	P	S	Q	E	(Kooy-Winkelaar et al. 2011)
DQ8.5-glia-γ1		P	Q	Q	S	F	P	E	Q	E	(Kooy-Winkelaar et al. 2011)
DQ8.5-glut-H1	HMW-glutenin	Q	G	Y	Y	P	T	S	P	Q	(Kooy-Winkelaar et al. 2011)

^aIn the epitope names, these short terms are used to denote the type of proteins that the epitopes derive from: ‘glia-α’ denotes α-gliadin, ‘glia-γ’ denotes γ-gliadin, ‘glia-ω’ denotes ω-gliadin, ‘glut-L’ denotes low molecular weight glutenin, ‘glut-H’ denotes high molecular weight glutenin, ‘hor’ denotes hordein, ‘sec’ denotes secalin and ‘ave’ denotes avenin

^bGlutamate residues (E) formed by TG2-medited deamidation which are important for recognition by T cells are shown in bold. Additional glutamine residues also targeted by TG2 are underlined