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. 2012 Mar;180(3):1232–1242. doi: 10.1016/j.ajpath.2011.12.009

Figure 5.

Figure 5

Neurotropic tumors express Sema4D, whereas nerves express plexin-B1. A: IHC analysis for Sema4D in normal tissues, tumors not known to exhibit PNI, or benign controls (low-PNI tumors/benign controls), and tumors known for PNI (high-PNI tumors), grouped by site of origin (mucosa, salivary gland, or prostate). HNSCC, high-grade MEC, ACC, PLGA, and prostate cancers demonstrate abundant Sema4D staining. Original magnification, ×20. B: Cross section of a nerve showing expression of plexin-B1. Original magnification, ×20. C: A scale of 0 to 3 was used to assess the number of positively stained cells; the staining intensity for Sema4D in the high-PNI tumor groups is shown. These two scores were added together to yield the ranges shown in the pie charts.