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Neurotropic tumors exhibit enhanced nerve density in a Sema4D-dependent manner. Analysis of neurofilament-stained sections of tumor xenografts composed of control-infected HN6 or HN12 cells (ctrl) or those infected with Sema4D shRNA-expressing lentivirus (Sema4D shRNA). Sema4D shRNA tumors exhibit less PNI and far fewer nerves. *P < 0.05, **P < 0.01.
