Skip to main content
. 2012 Apr;180(4):1474–1484. doi: 10.1016/j.ajpath.2011.12.032

Figure 3.

Figure 3

Effect of AIB1/SRC-3 on skin wound healing. Macroscopic images (A) and quantitation (B) of the open wound area of full-thickness dorsal skin wounds on day 5 after injury in AIB1/SRC-3+/+, +/−, and −/− mice. Values are given as the mean ± SEM (n = 3 to 11 animals per genotype). *P < 0.001, **P < 0.0001 versus control. C: Representative H&E-stained sections of excisional skin wounds on day 5 after wounding. Arrowheads, wound edges; arrows, tips of epithelial tongues. Scale bars: 0.2 mm. D: Quantitation of wound reepithelialization, as described in Materials and Methods. Values are given as the mean ± SEM (n = 3 to 5 animals per group). *P < 0.001 versus control. E: PCNA staining (brown) of proliferating cells (arrowheads) in the wound granulation tissue. Scale bars: 0.1 mm. F: Quantitation of the PCNA-positive nuclei. Proliferation index = PCNA-positive cell nuclei per 100 cells. Values are given as the mean ± SEM (n = 3 to 4 animals per group). *P < 0.001, ***P < 0.05 versus control. Macroscopic images (G) and quantitation (H) of the wound-healing time course of open wound areas in AIB1/SRC-3+/+ and +/− mice relative to day 0. Values are given as the mean ± SEM. **P < 0.0001 versus control.