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. 2012 Apr;180(4):1474–1484. doi: 10.1016/j.ajpath.2011.12.032

Figure 5.

Figure 5

Effect of AIB1/SRC-3 on wound angiogenesis and FGFR pathway genes. A: Representative H&E-stained sections of the granulation tissue from excisional skin wounds of AIB1/SRC-3+/+ and +/− mice on day 5 after wounding. Arrowheads, capillaries. Scale bars: 0.1 mm. B: Quantitation of the number of neocapillaries across the wound. Values are given as the mean ± SEM. *P < 0.05 versus control. C: Immunostaining of granulation tissue for microvessels with an anti–VEGF-A antibody. Arrowheads, VEGF-A positive endothelial cells. Scale bars: 0.1 mm. D: Quantitation of VEGF-A–positive neocapillaries. Values are given as the mean ± SEM (n = 3 to 5 animals per genotype group). **P < 0.001 versus control. E: mRNA expression (quantitative PCR) of FGF7, FGF10, FGFBP1, FGFBP3, and FGFR1 to FGFR4 in day 4 skin wounds. Values are given as the mean ± SEM (n = 3). *P < 0.05, **P < 0.001 versus control. Note that mice, in contrast to other vertebrates, lack the FGFBP2 gene.43,44