Figure 6.

Pancreatic mRNA expression of HMGB1 and TLR-4 mRNA. Pancreatic tissue was obtained from NOD mice (8 mice per time) every 3-5 weeks from 4 to 32 weeks of age and subjected to qRT-PCR. Values are means ± standard error of the mean. The data are from three independent experiments. ^*P < 0.05 (HMGB1) for 8 versus 10 weeks of age, 10 versus 12 weeks of age, 12 versus 16 weeks of age and 20 versus 26 weeks of age (Wilcoxon's signed rank test). ^**P < 0.05 (TLR4) for 4 versus 6 weeks of age, 6 versus 8 weeks of age, 8 versus 10 weeks of age, 12 versus 16 weeks of age, 16 versus 20 weeks of age and 26 versus 32 weeks of age (Wilcoxon's signed rank test).