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. Author manuscript; available in PMC: 2012 May 10.
Published in final edited form as: Exp Dermatol. 2008 Oct 22;18(1):1–11. doi: 10.1111/j.1600-0625.2008.00795.x

Figure 6.

Figure 6

Demonstration that the matrix gla protein (MGP) is under-carboxylated in the lesional skin of a patient with classic form of PXE (left panel) as well in a patient with PXE-like cutaneous features from the family in Figure 5 (middle panel), as compared to skin from a control individual (right panel). Skin biopsies were stained with specific antibodies recognizing either the under-carboxylated (ucMGP) or the carboxylated (cMGP) forms of MGP. The secondary antibodies consisted of biotin-conjugated anti-IgG, recognized by avidin-alkaline phosphatase conjugates, and visualized by incubation with an alkaline phosphatase substrate yielding red color (Modified from reference 59, with permission).