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Adrenomedullin Signaling in Development and Vascular Biology. (A.) Loss of AM signaling causes embryonic lethality due to severe edema associated with impaired lymphatic vascular development. (B.) In the adult, AM is an angiogenic, lymphangiogenic, and a cardioprotective factor that also regulates vascular permeability and inflammation. Expression of AM is also implicated in pregnancy and tumor progression.
