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. 2012 May 11;6:16. doi: 10.3389/fnint.2012.00016

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Copyright © 2012 Qin, Cousijn, Rijpkema, Luo, Franke, Hermans and Fernández.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits noncommercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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Stress-by-COMT genotype interaction effect on WM-related activity in the dorsolateral PFC. (A) Transversal (left panel) and coronal (right panel) view of activation in the right dorsolateral PFC showing significant stress-by-COMT genotype interaction effect. Statistical parametric maps are superimposed onto spatially normalized and averaged (n = 39) high-resolution T1-weighted images (thresholded at p < 0.001 uncorrected for visualization purposes). (B) Bar graphs representing parameter estimates of WM-related activation under control and stress conditions in Met-homozygotes (Met/Met) and Val-carriers. The data for these bar graphs were only extracted to illustrate the interaction effect. Note: Control, control condition; PFC, prefrontal cortex; Stress, stress condition; error bars in the graph represent standard error of mean; T, color coded t values obtained from the whole brain analysis.