Table 4. Complete in Vivo Pharmacokinetic Profile of Selected Analogues in Mice^a.

	IV PK parameters				PO PK parameters
entry	Vd(L/kg)	CL (mL/min/kg)	T1/2(h)	AUC(0–24 h)(h·nM)	Cmax(nM)	Tmax(h)	T1/2(h)	AUC(0–24 h)(h·nM)	F(%)
15	12.3	188.9	2.7	1072	235	2.0	4.20	965	15
22	10.2	49.2	2.0	4119	1538	1.0	4.35	12155	74
24	7.5	27.5	5.5	7062	1723	3.0	5.21	21058	75
27	23.7	60.0	6.2	3442	1803	1.7	8.95	17894	87
29	7.5	36.1	18.0	7607	1642	1.0	14.54	32409	107
34	2.7	12.5	2.8	16525	3651	1.0	2.71	50619	77
36	1.2	25.9	0.8	9090	6404	1.0	2.95	19447	53

^aPO dosing; dose (mg/kg), 20; species/strain, mouse, male balb/c; formulation, 2.5 mg/mL in PEG300/D5W, 3:1, solution; V_d = volume of distribution; CL = clearance; C_max = maximal concentration; T_max = time at maximal concentration; AUC = area under the curve; F = oral bioavailability.