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. 2012 Apr 23;55(9):4244–4273. doi: 10.1021/jm300041e

Table 6. Rat Snapshot PK Results for Interesting Compoundsa.

  PK parameters
entry AUC(0–5 h)(h·nM) Cmax(nM) AUC(0–5 h)/dose[(min·μg/mL)/(mg/kg)]
22 487 126 1.2
24 367 96.66 0.95
29 NA BLQ  
34 2097 504.44 5.07
36 423 202 0.9
a

PO dosing; dose (mg/kg), 20; species/strain, rat, Wistar; formulation, 2.5 mg/mL in PEG300/D5W, 3:1, solution; BLQ, below level of quantification; NA = could not be determined.