Table 6. Rat Snapshot PK Results for Interesting Compoundsa.
PK parameters |
|||
---|---|---|---|
entry | AUC(0–5 h)(h·nM) | Cmax(nM) | AUC(0–5 h)/dose[(min·μg/mL)/(mg/kg)] |
22 | 487 | 126 | 1.2 |
24 | 367 | 96.66 | 0.95 |
29 | NA | BLQ | |
34 | 2097 | 504.44 | 5.07 |
36 | 423 | 202 | 0.9 |
PO dosing; dose (mg/kg), 20; species/strain, rat, Wistar; formulation, 2.5 mg/mL in PEG300/D5W, 3:1, solution; BLQ, below level of quantification; NA = could not be determined.