Figure 4.

MD-equilibrated trimers of the modeled substrate translocation path (STP) for GltPh shown in the reference frame of the lipid membrane (phosphor atoms as gray beads, lipid tail carbon atoms as cyan lines) for (a) OfCC, (b) IfCC, (c) MDi.4, and (d) MDi.5. The center of mass of the three transport domains (orange) is indicated by a red sphere; the center of mass for the trimerization domains (green) is marked by a blue sphere; residues 130–168 (TM4a–c) in monomer B were omitted for clarity. The angle between the membrane normal (black bar) and TM6 of monomer A (purple helix) is inscribed in black. Substrates are rendered as colored sticks.