Table 1.
Cardiac measurements in WT and CypD–/– mice assessed at 2 and 28 days following sham surgery or MI
| 2 days | Sham | MI | ||
|---|---|---|---|---|
| WT | CypD–/– | WT | CypD–/– | |
| n number | 3 | 4 | 11 | 10 |
| Heart rate (bpm) | 564.1 ± 26.8 | 565.6 ± 9.1 | 552.5 ± 20.1 | 554.3 ± 16.7 |
| LVEDD (cm) | 0.37 ± 0.03 | 0.35 ± 0.01 | 0.40 ± 0.01 | 0.41 ± 0.02 |
| LVESD (cm) | 0.24 ± 0.02 | 0.23 ± 0.01 | 0.30 ± 0.01 | 0.28 ± 0.02 |
| FS (%) | 35.8 ± 1.4 | 33.7 ± 1.4 | 24.8 ± 1.0* | 31.8 ± 1.9† |
| EF (%) | 71.6 ± 1.4 | 70.2 ± 1.4 | 55.8 ± 1.6* | 66.4 ± 2.5† |
| 28 days | Sham | MI | ||
| WT | CypD–/– | WT | CypD–/– | |
| n number | 7 | 7 | 10 | 10 |
| Body weight, BW (g) | 28.2 ± 0.5 | 28.4 ± 0.3 | 29.6 ± 0.6 | 27.3 ± 0.7† |
| Heart weight, HW (mg) | 153.2 ± 4.9 | 163.2 ± 4.9 | 250.5 ± 16.4* | 223.4 ± 10.1* |
| HW/BW (mg/g) | 5.44 ± 0.2 | 5.7 ± 0.2 | 8.4 ± 0.4* | 8.2 ± 0.4* |
| Heart rate (bpm) | 550.7 ± 24.3 | 485.4 ± 26.6 | 501.7 ± 21.4 | 497.1 ± 21.0 |
| LVEDD (cm) | 0.38 ± 0.02 | 0.38 ± 0.02 | 0.47 ± 0.02* | 0.40 ± 0.02 |
| LVESD (cm) | 0.25 ± 0.02 | 0.24 ± 0.01 | 0.39 ± 0.02* | 0.30 ± 0.02† |
| FS (%) | 34.3 ± 3.1 | 36.0 ± 2.0 | 17.8 ± 1.3* | 26.8 ± 1.8*† |
| EF (%) | 69.1 ± 4.1 | 72.4 ± 2.3 | 41.0 ± 2.8* | 58.0 ± 2.8*† |
LVEDD: left ventricular end-diastolic diameter; LVESD: left ventricular end-systolic diameter; FS: fractioning shortening; EF: ejection fraction.
*
P < 0.05 versus respective sham, †P <0.05 versus MI WT.