Table 2.

Adjusted rate ratios for serious cardiovascular events, associated with ADHD medication use, remote use comparison

Medication status	Person- yrs	Number Events	Rate/1,000 person-yrs	Unadjusted RR	Adjusted matching variables RRa	Adjusted RRb	95% CI
MI
Current use	113,324.2	152	1.34	0.64	0.98	1.08	0.86 – 1.36
Amphetamines	49,080.1	59	1.20	0.57	0.99	1.12	0.83 – 1.52
Methylphenidate	51,232.8	77	1.50	0.71	1.00	1.10	0.83 – 1.45
Atomoxetine	8,424.8	11	1.31	0.62	0.99	1.06	0.57 – 1.96
Pemoline	3,047.3	5	1.64	0.78	0.87	0.87	0.36 – 2.12
Multiple	1,539.1	0	0.00	--	--	--	--
Indeterminate use	53,896.7	86	1.60	0.76	1.19	1.31	1.00 – 1.71
Former use	47,858.5	65	1.36	0.64	0.92	0.96	0.71 – 1.28
Remote use	69,792.9	147	2.11	1.00	1.00	1.00	reference
SCDc
Current use	107,525.0	32	0.30	0.41	0.79	0.82	0.52 – 1.29
Amphetamines	46,910.0	13	0.28	0.38	0.85	0.94	0.51 – 1.76
Methylphenidate	47,887.1	13	0.27	0.37	0.66	0.68	0.37 – 1.27
Atomoxetine	8,257.6	4	0.48	0.66	1.14	1.06	0.38 – 2.95
Pemoline	2,995.7	2	0.67	0.91	1.11	1.10	0.27 – 4.56
Multiple	1,474.5	0	0.00	--	--	--	--
Indeterminate use	51,814.0	14	0.27	0.37	0.70	0.74	0.41 – 1.35
Former use	46,263.5	20	0.43	0.59	0.94	0.92	0.55 – 1.55
Remote use	68,102.6	50	0.73	1.00	1.00	1.00	reference
Stroked
Current use	111,935.5	63	0.56	0.58	0.90	0.93	0.65 – 1.31
Amphetamines	48,672.9	19	0.39	0.40	0.70	0.77	0.46 – 1.29
Methylphenidate	50,332.3	39	0.77	0.80	1.15	1.15	0.77 – 1.72
Atomoxetine	8,371.1	3	0.36	0.37	0.55	0.54	0.17 – 1.71
Pemoline	3,030.1	2	0.66	0.68	0.74	0.72	0.18 – 2.96
Multiple	1,529.2	0	0.00	--	--	--	--
Indeterminate use	53,327.8	31	0.58	0.60	0.96	1.01	0.65 – 1.54
Former use	47,333.0	39	0.82	0.85	1.24	1.23	0.83 – 1.83
Remote use	69,202.3	67	0.97	1.00	1.00	1.00	reference
MI, SCD or strokec,d
Current use	107,322.4	234	2.18	0.61	0.96	1.03	0.86 – 1.24
Amphetamines	46,826.5	88	1.88	0.52	0.93	1.05	0.82 – 1.34
Methylphenidate	47,792.3	120	2.51	0.70	1.01	1.07	0.86 – 1.34
Atomoxetine	8,248.2	17	2.06	0.57	0.90	0.92	0.56 – 1.50
Pemoline	2,985.2	9	3.01	0.84	0.95	0.93	0.48 – 1.82
Multiple	1,470.1	0	0.00	--	--	--	--
Indeterminate use	51,709.6	125	2.42	0.67	1.09	1.17	0.94 – 1.45
Former use	46,120.8	121	2.62	0.73	1.06	1.07	0.86 – 1.33
Remote use	67,489.0	243	3.60	1.00	1.00	1.00	reference

Abbreviations: MI, myocardial infarction; SCD, sudden cardiac death; RR, rate ratio; CI, confidence interval; CRS, cardiovascular risk score; KP, Kaiser Permanente

^aAdjusted for site, age, sex, and calendar year (ie, matching variables).

^bAdjusted for site, age, sex, calendar year, and CRS (some variables within score are time-varying).

^cAnalyses excluded the three HMORN sites (Fallon Community, KP Georgia, KP Northwest) that did not provide data on SCD endpoints.

^dAnalyses excluded the two HMORN sites (Fallon Community, KP Georgia) that did not provide data on stroke endpoints.