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. Author manuscript; available in PMC: 2012 May 11.
Published in final edited form as: J Endocrinol. 2011 Jan 4;208(3):311–322. doi: 10.1530/JOE-10-0413

Figure 2.

Figure 2

Effects of CORT pretreatment on basal and stress-induced ACTH plasma hormone levels of non-CX or CX pretreated rats. (A) In the absence of CX pretreatment, restraint significantly increased plasma ACTH levels and this was suppressed by both 1 h and 3 h CORT pretreatment. (B) Systemic pretreatment with CX induced high secretion of ACTH that declined some over the 3.5 h after treatment. CX prevented the suppressive effect of CORT pretreatment on plasma ACTH levels. *, represents a significant stress effect within same drug condition and pretreatment time point (p < 0.05, FLSD); +, represents a significant CORT effect compared to vehicle treated rats within the same pretreatment time and stress condition (p < 0.05, FLSD); #, represents a significant difference in ACTH secretion between 1 h and 3 h pretreatments within CX treated rats (p < 0.05, FLSD); R, represents a significant difference between CX pretreated rats (B) compared to the corresponding non-CX treated rats (A) (p < 0.05, FLSD).