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. Author manuscript; available in PMC: 2012 May 11.
Published in final edited form as: J Endocrinol. 2011 Jan 4;208(3):311–322. doi: 10.1530/JOE-10-0413

Figure 3.

Figure 3

Effects of CORT pretreatment on basal and stress-induced CORT levels of non-CX or CX pretreated rats. (A) In the absence of CX pretreatment, endogenous CORT levels were significantly increased by 15 min of restraint (evident in vehicle pretreatment groups). Exogenous CORT levels cleared from the circulation by 3 h after treatment, at which time it was evident that stress-induced endogenous CORT was suppressed. (B) Systemic pretreatment with CX prevented stress-induced production of endogenous CORT, and appeared to interfer with the rate of clearance of exogenous CORT. *, represents a significant stress effect within same drug condition and pretreatment time point (p < 0.05, FLSD); +, represents a significant CORT effect compared to vehicle treated rats within the same pretreatment time and stress condition (p < 0.05, FLSD); R, represents a significant difference between CX pretreated rats (B) compared to the corresponding non-CX treated rats (A) (p < 0.05, FLSD).