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. Author manuscript; available in PMC: 2012 May 11.
Published in final edited form as: J Endocrinol. 2011 Jan 4;208(3):311–322. doi: 10.1530/JOE-10-0413

Figure 4.

Figure 4

Effects of CORT pretreatment on basal and stress-induced PVN crh hnRNA levels of non-CX or CX pretreated rats. (A,B) In the absence of CX pretreatment, restraint significantly induced PVN crh hnRNA and pretreatment with CORT 1 h, but not 3 h, prior to restraint suppressed this effect. (C,D) Systemic pretreatment with CX increased PVN crh hnRNA levels in all groups, but did not block the suppressive effect of 1 h CORT pretreatment on crh hnRNA levels. Panels B and D show representative autoradiographic images of the bilateral PVN portion of coronal brain sections from key comparison conditions depicted in panels A and C, respectively. Values are presented as a percentage of the mean value of the non-CX pretreated stressed 3 h vehicle rats. *, represents a significant stress effect within same drug condition and pretreatment time point (p < 0.05, FLSD); +, represents a significant CORT effect compared to vehicle treated rats within the same pretreatment time and stress condition (p < 0.05, FLSD); R, represents a significant difference between CX pretreated rats (C) compared to the corresponding non-CX treated rats (A) (p < 0.05, FLSD).